Jove
Visualize
Contact Us

Related Experiment Videos

Structural insight into microtubule function.

E Nogales1

  • 1Department of Molecular and Cell Biology, University of California, Berkeley, and Lawrence Berkeley National Laboratory, Berkeley California 94720, USA. ENOGALES@LBL.GOV

Annual Review of Biophysics and Biomolecular Structure
|July 10, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Current outcomes when optimizing 'standard' sample preparation for single-particle cryo-EM.

Journal of microscopy·2019
Same author

Size-selective breaking of the core-shell structure of gallium nanoparticles.

Nanotechnology·2018
Same author

Preparing recombinant yeast septins and their analysis by electron microscopy.

Methods in cell biology·2016
Same author

Visible cathodoluminescence of Er ions in β-Ga(2)O(3) nanowires and microwires.

Nanotechnology·2011
Same author

Cathodoluminescence of rare earth implanted Ga2O3 and GeO2 nanostructures.

Nanotechnology·2011
Same author

Accurate modeling of single-particle cryo-EM images quantitates the benefits expected from using Zernike phase contrast.

Journal of structural biology·2011
Same journal

Regulation of actin filament assembly by Arp2/3 complex and formins.

Annual review of biophysics and biomolecular structure·2007
Same journal

Living with noisy genes: how cells function reliably with inherent variability in gene expression.

Annual review of biophysics and biomolecular structure·2007
Same journal

Physics of proteins.

Annual review of biophysics and biomolecular structure·2007
Same journal

Fluorescence correlation spectroscopy: novel variations of an established technique.

Annual review of biophysics and biomolecular structure·2007
Same journal

Structural mechanisms underlying posttranslational modification by ubiquitin-like proteins.

Annual review of biophysics and biomolecular structure·2007
Same journal

From "simple" DNA-protein interactions to the macromolecular machines of gene expression.

Annual review of biophysics and biomolecular structure·2007
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Microtubules, essential for cell transport and division, are regulated by complex processes including tubulin dynamics and associated proteins. Recent structural studies offer new insights into microtubule function and drug interactions.

Area of Science:

  • Cell Biology
  • Cytoskeleton Dynamics

Background:

  • Microtubules are essential eukaryotic polymers involved in cell transport and division.
  • Microtubule regulation involves tubulin isotype transcription, heterodimer folding, post-translational modifications, and microtubule-associated proteins.

Purpose of the Study:

  • To explore the intricate regulation of the microtubule cytoskeleton.
  • To understand the impact of recent structural analyses on microtubule research.

Main Methods:

  • High-resolution structural analysis of tubulin and microtubules.
  • Integration of structural data with genetic, biochemical, and biophysical approaches.

Main Results:

  • Recent structural studies provide novel insights into microtubule function and regulation.

Related Experiment Videos

  • Understanding of antimitotic drug mechanisms is enhanced by new structural data.

    • Conclusions:

    • Combining diverse data types promises a comprehensive understanding of microtubule cytoskeleton regulation.
    • Further research will elucidate the precise mechanisms governing microtubule dynamics and cellular roles.