Related Experiment Videos
Unusual imaging findings in progressive myoclonus epilepsy
R A Marrie1, E A Shoubridge, J P Antel
1Department of Neurology, McGill University, Montreal, Quebec, Canada.
Epilepsia
|July 10, 2001
Abstract:
We describe a patient with progressive myoclonus epilepsy (PME), white matter hyperintensities in the corpus callosum, cerebral hemispheres, and left cerebral peduncle on magnetic resonance imaging (MRI), and positive oligoclonal bands. A phosphorus magnetic resonance spectrum was compatible with mitochondrial dysfunction. Abnormal white matter signals are not a feature of the known PME syndromes, although they occur in Leber's hereditary optic neuropathy (LHON). These abnormalities oriented the diagnosis toward mitochondrial disease.