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Related Experiment Videos

Immunoisolation cell therapy for CNS diseases.

D F Emerich1, S R Winn

  • 1Department of Neuroscience, Alkermes, Inc, Cambridge MA 02139, USA.

Critical Reviews in Therapeutic Drug Carrier Systems
|July 10, 2001
PubMed
Summary

Cellular implants using immunoisolation overcome the blood-brain barrier (BBB) to deliver therapeutics directly to the central nervous system (CNS). This review details device configurations, manufacturing, preclinical models, and clinical trial status for this cell-based therapy.

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Drug Delivery

Background:

  • The blood-brain barrier (BBB) restricts drug entry into the central nervous system (CNS).
  • Cellular implants offer a method to bypass the BBB for localized drug delivery.
  • Immunoisolation utilizes selectively permeable membranes to encapsulate therapeutic cells.

Purpose of the Study:

  • To review the current status of cell-based therapy using immunoisolation for CNS diseases.
  • To discuss device configurations, membrane manufacturing, and preclinical characterization.
  • To outline the progress of clinical trials for immunoisolation therapies.

Main Methods:

  • Review of literature on cell-based therapies for CNS disorders.
  • Analysis of immunoisolation device designs and membrane fabrication techniques.

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  • Evaluation of preclinical studies and clinical trial data.

    • Main Results:

    • Immunoisolation presents a viable strategy for delivering therapeutic molecules across the BBB.
    • Various device configurations and membrane materials have been developed.
    • Preclinical models demonstrate the efficacy and safety of encapsulated cells.
    • Early-stage clinical trials are underway for specific CNS conditions.

    Conclusions:

    • Cellular immunoisolation is a promising approach for treating CNS diseases by overcoming BBB limitations.
    • Further research and clinical development are essential to optimize this therapeutic strategy.
    • Successful translation of immunoisolation therapies could revolutionize CNS treatment.