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Feedback control of a biodynamical model of HIV-1
1Neurosignal Analysis Laboratory, School of Health Information Sciences, University of Texas Health Science Center, Houston 77030, USA. Michael.E.Brandt@uth.tmc.edu
IEEE Transactions on Bio-Medical Engineering
|July 10, 2001
Abstract:
We describe a continuous differential equation model of the interaction dynamics of HIV-1 and CD4 and CD8 lymphocytes in the human body. We demonstrate several methods of stable control of the HIV-1 population using an external feedback control term that is analogous to the introduction of a therapeutic drug regimen. We also show how the immune system components can be bolstered against the virus through a feedback control approach.