Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clinical trials in ALS: an overview.

M R Turner1, M J Parton, P N Leigh

  • 1Department of Neurology, Institute of Psychiatry, London, UK.

Seminars in Neurology
|July 10, 2001
PubMed
Summary

Clinical trials for amyotrophic lateral sclerosis (ALS) have yielded limited success, with most drugs failing to produce a cure. This review details past and recent ALS drug trials, highlighting challenges in trial design and assessment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of Real-World Perturbations on Wave Breaking due to a Sharp-Crested Superharmonic Instability.

Water waves (Cham, Switzerland)·2025
Same author

Evaluation of cerebrospinal fluid alpha-synuclein seed amplification assay in PSP and CBS.

medRxiv : the preprint server for health sciences·2024
Same author

Neurophysiological features of primary lateral sclerosis.

Amyotrophic lateral sclerosis & frontotemporal degeneration·2021
Same author

Lagrangian particle path formulation of multilayer shallow-water flows dynamically coupled to vessel motion.

Journal of engineering mathematics·2020
Same author

The two-year progression of structural and functional cerebral MRI in amyotrophic lateral sclerosis.

NeuroImage. Clinical·2018
Same author

Cytosolic 5'-nucleotidase 1A autoantibody profile and clinical characteristics in inclusion body myositis.

Annals of the rheumatic diseases·2017

Area of Science:

  • Neurology
  • Clinical Epidemiology
  • Drug Development

Background:

  • Amyotrophic lateral sclerosis (ALS) research has a long history of clinical trials, yet a cure remains elusive.
  • Despite numerous drug investigations, most clinical trials for ALS have yielded negative results.
  • Advancements in molecular biology and epidemiology offer new therapeutic avenues for ALS.

Purpose of the Study:

  • To document all published clinical trials for drugs tested in amyotrophic lateral sclerosis (ALS) treatment.
  • To provide a detailed focus on recent large, multicenter trials involving specific novel therapeutic agents.
  • To critically review the challenges and parameters in designing and assessing ALS clinical trials.

Main Methods:

  • Comprehensive review of published clinical trial data for amyotrophic lateral sclerosis (ALS) treatments.
  • Detailed analysis of large, multicenter trials for riluzole, ciliary neurotrophic factor, insulin-like growth factor-I, brain-derived neurotrophic factor, and SR57746A.
  • Examination of trial design issues, including endpoint selection and surrogate markers for disease progression.

Main Results:

  • Over fifty years of ALS clinical trials have explored numerous drugs with limited therapeutic success.
  • Recent large-scale trials have investigated promising agents like riluzole and various growth factors.
  • Significant challenges persist in optimizing ALS clinical trial design and outcome assessment.

Conclusions:

  • Despite extensive research, effective treatments for amyotrophic lateral sclerosis (ALS) remain a significant challenge.
  • Improvements in trial design, endpoint selection, and statistical analysis are crucial for future ALS drug development.
  • A rigorous ethical framework and robust methodology are essential for advancing ALS therapeutics.

Related Experiment Videos