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Development and application of a carbonyl-(13)C-enriched backbone amide linker for solid-phase reaction monitoring
C Jamieson1, M S Congreve, P R Hewitt
1Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Journal of Combinatorial Chemistry
|July 10, 2001
Abstract:
The synthesis and application of a carbonyl-(13)C backbone amide linker are described. The labeled unit is conveniently mixed with commercial resins, providing a rapid means of monitoring chemistry performed with this linker on solid support using conventional (13)C NMR methods.