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Clinical trial of acetazolamide in SCA6, with assessment using the Ataxia Rating Scale and body stabilometry
I Yabe1, H Sasaki, I Yamashita
1Department of Neurology, Hokkaido University School of Medicine, Sapporo 060-8638, Japan.
Objective:
To investigate the effect of acetazolamide on spinocerebellar ataxia type 6 (SCA6).
Methods:
Acetazolamide (250-500 mg/day) was administered orally for 88 weeks to 6 patients with SCA6, and its effect was quantitatively monitored using the Ataxia Rating Scale (ARS) and body sway analysis by stabilometry.
Results:
During administration of acetazolamide, the ARS score and the amplitude of body sway were significantly reduced compared with before administration. However, the response became weaker after 1 year of treatment.
Conclusion:
Although this was an open trial, the results suggested that acetazolamide can temporarily reduce the severity of symptoms during the progression of SCA6.
