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Updated: Sep 18, 2026

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Published on: May 7, 2011
Comparison of caudal morphine and tramadol for postoperative pain control in children undergoing inguinal
D Ozcengiz1, M Gunduz, H Ozbek
1Department of Anaesthesiology, Faculty of Medicine, Cukurova University, 01330 Balcal 1, Adana, Turkey. ecenaz@mail.cu.edu.tr
Insights
Caudal tramadol and morphine offer comparable postoperative pain relief in children undergoing herniorrhaphy. Presurgical administration of either agent reduced sevoflurane requirements during surgery.
Area of Science:
- Pediatric Anesthesiology
- Pain Management
- Pharmacology
Background:
- Caudal blocks are used for pediatric pain management.
- Tramadol and morphine are common analgesics.
- Preemptive analgesia aims to reduce pain sensitivity.
Purpose of the Study:
- Compare tramadol and morphine for caudal analgesia in pediatric herniorrhaphy.
- Evaluate the effect on perioperative sevoflurane requirements.
- Assess preemptive analgesic efficacy.
Main Methods:
- Randomized controlled trial with three groups: preemptive tramadol, preemptive morphine, and postincisional morphine.
- Dosages: tramadol 2 mg/kg, morphine 0.03 mg/kg.
- Monitored cardiorespiratory data, sedation, and pain for 24 hours.
Main Results:
- Sevoflurane concentration was lower in tramadol and morphine groups compared to control.
- No significant differences in pain relief quality or duration between groups.
- No differences in postoperative nausea, vomiting, or complications.
Conclusions:
- Caudal tramadol provides reliable postoperative analgesia, similar to caudal morphine.
- Presurgical caudal morphine or tramadol decreases perioperative sevoflurane needs.
- Timing of caudal morphine (pre- vs. post-incision) did not impact postoperative analgesia.
Objectives:
We compared the quality and duration of analgesia, the effect on perioperative sevoflurane requirement after a single, presurgical caudal block with either tramadol or morphine in children undergoing inguinal herniorrhaphy. Our study was also designed to evaluate the preemptive analgesic efficacy of morphine administered caudally in children.
Methods:
Patients were randomly divided into three groups to receive 2 mg.kg-1 tramadol (group T, preemptive group) or morphine sulphate 0.03 mg.kg-1 (group M, preemptive group). The patients in control group (group C, postincisional group) received morphine sulphate 0.03 mg.kg-1 at the end of surgery, caudally. Cardiorespiratory data, sedation and pain were recorded for 24 h following recovery from anaesthesia.
Results:
There were no differences between the three groups in baseline blood pressure or heart rate; or duration of anaesthesia, surgery. The inhaled sevoflurane concentration was significantly lower in group M and group T than in the control group. The quality and duration of postoperative pain relief did not differ between the three groups. There were no intergroup differences in postoperative nausea, vomiting, or other complications.
Conclusion:
Caudal tramadol (2 mg.kg-1) provided reliable postoperative analgesia similar to caudal morphine (0.03 mg.kg-1) in quality and duration of pain relief in our study children who were undergoing herniorrhaphy. We also concluded that presurgical caudal morphine or tramadol reduced perioperative sevoflurane requirements and either presurgical or postsurgical caudal morphine did not make any difference to postoperative analgesia.
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