Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypoxia-dependent protein expression: erythropoietin.

M Samaja1

  • 1Dipartimento di Medicina, Chirurgia e Odontoiatria, Università di Milano, Milan, Italy. Michele.Samaja@unimi.it

High Altitude Medicine & Biology
|July 10, 2001
PubMed
Summary

Cellular dysfunction and death occur when metabolic pathways are disrupted, particularly under conditions of hypoxia. This review examines erythropoiesis as a key response to low oxygen, with implications for clinical applications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

COVID-19-associated cardiovascular morbidity in older adults: a position paper from the Italian Society of Cardiovascular Researches.

GeroScience·2020
Same author

Inhibition of ceramide de novo synthesis as a postischemic strategy to reduce myocardial reperfusion injury.

Basic research in cardiology·2016
Same author

Glutathionyl-hemoglobin levels in carotid endarterectomy: a pilot study on 12 cases clinically uneventful.

The Journal of cardiovascular surgery·2013
Same author

CO-MP4, a polyethylene glycol-conjugated haemoglobin derivative and carbon monoxide carrier that reduces myocardial infarct size in rats.

British journal of pharmacology·2008
Same author

Metabolic modulation induced by chronic hypoxia in rats using a comparative proteomic analysis of skeletal muscle tissue.

Journal of proteome research·2007
Same author

Trimetazidine reduces basal cytosolic Ca2+ concentration during hypoxia in single Xenopus skeletal myocytes.

Experimental physiology·2003

Area of Science:

  • Physiology
  • Cell Biology
  • Biochemistry

Background:

  • Cellular homeostasis depends on metabolic pathways; disruptions lead to dysfunction and death.
  • Hypoxia, from high altitudes or disease, is a significant threat to cell viability.
  • Organisms employ adaptive and maladaptive responses to hypoxia, but severe cases are invariably fatal.

Purpose of the Study:

  • To review erythropoiesis as a primary mechanism of cellular response to hypoxia.
  • To explore the clinical applications of research on hypoxia-induced erythropoiesis.

Main Methods:

  • Literature review of cellular responses to hypoxia.
  • Analysis of the biochemical mechanisms of erythropoiesis.
  • Examination of high-altitude adaptation and clinical translation.

Main Results:

  • Erythropoiesis is a critical, though not always beneficial, response to reduced oxygen availability.
  • Understanding erythropoiesis has led to research translating high-altitude adaptations to clinical settings.

Conclusions:

  • Hypoxia profoundly impacts cellular function and viability.
  • Erythropoiesis research offers valuable insights for clinical interventions in hypoxic conditions.

Related Experiment Videos