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Related Concept Videos

Arboviral Encephalitis01:25

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
Encephalitis l: Introduction01:19

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
Encephalitis ll: Pathophysiology01:26

Encephalitis ll: Pathophysiology

Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...

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Related Experiment Video

Updated: Jul 5, 2026

Bacterial Artificial Chromosomes: A Functional Genomics Tool for the Study of Positive-strand RNA Viruses
12:20

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[Synthesis, immunogenicity and antigenic characteristics of the glycoprotein E fragments from the tick-borne

T D Volkova1, O M Vol'pina, M N Zhmak

  • 1Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, GSP Moscow, 117997 Russia. tdvolkova@mail.ibch.ru

Bioorganicheskaia Khimiia
|July 11, 2001
PubMed
Summary

Researchers synthesized tick-borne encephalitis virus (TBEV) envelope protein E peptides. Five peptides showed immunogenicity in mice, and two recognized TBEV antibodies, showing promise for diagnostic tools.

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Area of Science:

  • Virology
  • Immunology
  • Peptide Synthesis

Context:

  • Tick-borne encephalitis virus (TBEV) poses a significant public health threat.
  • The envelope protein E is a key target for TBEV immunity.
  • Developing effective diagnostic tools for TBEV is crucial.

Purpose:

  • To synthesize peptide fragments of the TBEV envelope protein E.
  • To evaluate the immunogenicity of these peptides in mice without carriers.
  • To identify peptides that bind to TBEV-specific antibodies.

Summary:

  • Six peptide fragments of TBEV envelope protein E, including T-helper epitopes, were synthesized.
  • Five peptides demonstrated immunogenic properties in mice, varying with mouse haplotype.
  • Two peptides showed high affinity for TBEV antibodies in equine and human sera.

Impact:

  • Identified immunogenic peptides for potential TBEV vaccine development.
  • Discovered two peptides with high diagnostic potential for TBEV detection.
  • These findings contribute to advancing TBEV diagnostics and therapeutics.