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[Polymethylene derivatives of nucleic bases with omega-functional groups. II. Adenine and hypoxanthine derivatives]
A A Makinskiĭ1, A M Kritsyn, E A Ul'ianova
1Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, ul. Vavilova 32, GSP-1 Moscow, 119991 Russia.
Bioorganicheskaia Khimiia
|July 11, 2001
Abstract:
N9-Polymethylene derivatives of adenine and hypoxanthine with various functional groups in the omega-position of the alkyl substituent were synthesized. Their physico-chemical properties and effect on the HIV reverse transcriptase and DNA topoisomerase I were studied.