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Related Experiment Videos

Second malignancies in melanoma patients in Thuringia.

J Wolff1, U Wollina

  • 1Department of Dermatology and Allergology, Friedrich-Schiller-University of Jena, Germany.

Journal of the European Academy of Dermatology and Venereology : JEADV
|July 11, 2001
PubMed
Summary

Melanoma patients have an 11% risk of developing secondary skin cancers, including basal cell carcinoma (BCC) and new melanomas. Regular dermatological follow-up is recommended, as these secondary tumors did not significantly impact overall survival in this study.

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Area of Science:

  • Oncology
  • Dermatology
  • Epidemiology

Background:

  • The incidence of malignant melanoma is rising globally.
  • Melanoma survivors face an increased risk of developing subsequent primary cancers (second neoplasias).
  • Limited data exists on secondary malignancy patterns in Eastern Germany.

Purpose of the Study:

  • To determine the frequency, types, and sites of secondary malignancies in melanoma patients.
  • To assess the impact of second neoplasias on the survival rates of melanoma patients.
  • To inform follow-up care strategies for individuals with a history of melanoma.

Main Methods:

  • A retrospective study was conducted at the Melanoma Outpatient Clinic, University of Jena, Germany (1966-1999).
  • Included 554 patients diagnosed with malignant melanoma (237 male, 317 female).

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  • A case-comparison mortality study, log-rank test, and chi2-test were employed for statistical analysis with a mean follow-up of 5.6 years.

    • Main Results:

    • 11.0% of melanoma patients (61/554) developed at least one second tumor; 83 second tumors were recorded in total.
    • Basal cell carcinoma (BCC) was the most common secondary malignancy (17 patients, 22 tumors).
    • Second melanomas occurred in 15 patients, with a significantly lower mean tumor thickness (0.81 mm) compared to primary melanomas (1.92 mm). Breast cancer was diagnosed in 7 female patients (8 cancers).

    Conclusions:

    • Second malignancies, particularly skin cancers like BCC and additional melanomas, are significant in melanoma survivors.
    • Regular dermatological surveillance is crucial for early detection of secondary skin tumors.
    • The development of second tumors (BCC, melanoma, breast cancer) did not demonstrate a statistically significant negative impact on overall patient survival in this cohort with regular follow-up.