Related Experiment Video

Updated: Jun 29, 2026

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
09:03

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice

Published on: February 3, 2012

Induction of hepatitis in adult Syrian hamster by H-1 virus

C J Henry, A F Diorio

    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
    |May 1, 1975
    PubMed

    Abstract:

    The induction of hepatitis in adult hamster by H-1 virus was documented by demonstrating an increase in serum SGOT and SGPT at 3-9 wk postinoculation. The electrophoresis pattern of LDH isoenzymes showed a marked increase in the liver fraction (fraction 5) indicating liver damage in infected hamsters. The pathology displayed in diseased livers revealed a focal degeneration of hepatic cells although infiltration of white cells was not observed. H-1 virus is apparently capable of producing hepatitis (without symptoms) in adult hamsters as well as cause hepatitis and severe cerebral disease in newborn hamsters.

    Keywords:
    viral pathogenesishepatic degenerationserum enzymeslactate dehydrogenase

    More Related Videos

    Production of Genetically Engineered Golden Syrian Hamsters by Pronuclear Injection of the CRISPR/Cas9 Complex
    06:12

    Production of Genetically Engineered Golden Syrian Hamsters by Pronuclear Injection of the CRISPR/Cas9 Complex

    Published on: January 9, 2018

    Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
    11:36

    Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

    Published on: May 29, 2020

    Related Experiment Videos

    Last Updated: Jun 29, 2026

    The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
    09:03

    The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice

    Published on: February 3, 2012

    Production of Genetically Engineered Golden Syrian Hamsters by Pronuclear Injection of the CRISPR/Cas9 Complex
    06:12

    Production of Genetically Engineered Golden Syrian Hamsters by Pronuclear Injection of the CRISPR/Cas9 Complex

    Published on: January 9, 2018

    Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
    11:36

    Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

    Published on: May 29, 2020

    Related Concept Videos

    Hepatitis01:25

    Hepatitis

    Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
    Viral Hepatitis I: Introduction01:28

    Viral Hepatitis I: Introduction

    Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...

    Articles linked to this work by shared authors, journal, and citation graph.

    The SINgapore GERiatric Intervention Study to Reduce Cognitive Decline and Physical Frailty (SINGER): Study Design and Protocol.

    The journal of prevention of Alzheimer's disease·2022

    Donor-site local anaesthetic infusion catheter as an opioid-sparing agent in free flap reconstruction of the head and neck: a valuable adjunct to an enhanced recovery protocol.

    The British journal of oral & maxillofacial surgery·2021

    Inflexibility of the plasma miRNA response following a high-carbohydrate meal in overweight insulin-resistant women.

    Genes & nutrition·2020

    Brown fat activity determined by infrared thermography and thermogenesis measurement using whole body calorimetry (BRIGHT Study).

    Physiological research·2019

    Clinical Evaluation of Tavocept to Decrease Diuresis Time and Volume in Dogs with Bladder Cancer Receiving Cisplatin.

    Journal of veterinary internal medicine·2017

    Body composition measurement in young children using quantitative magnetic resonance: a comparison with air displacement plethysmography.

    Pediatric obesity·2017

    Evaluation of the collection and storage of packed red blood cells in ferrets.

    The Veterinary record·2026

    Peripheral pulmonary arterial stenosis due to lung tumor in a cat.

    The Journal of veterinary medical science·2026

    Sivelestat sodium improves post-resuscitation brain outcomes possibly by inhibiting cell pyroptosis via inactivating the cGAS/STING/TBK1 pathway.

    Neuroscience letters·2026

    The Comparative Prognostic Value of the Interim PET Deauville Score and ΔSUVmax in Classical Hodgkin Lymphoma: A Real-World Study of Imaging and Inflammatory Markers.

    Journal of clinical medicine·2026

    Highly-Time-Resolved Measurements of Tryptophan's Distribution and Homeostatic Regulation in Live, Intact Animals.

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

    Development and Characterization of a Rat Model of Post-traumatic Ankle Osteoarthritis.

    Osteoarthritis and cartilage·2026
    See all related articles
    JoVE
    x logofacebook logolinkedin logoyoutube logo
    ABOUT JoVE
    OverviewLeadershipBlogJoVE Help Center
    AUTHORS
    Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
    LIBRARIANS
    TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
    RESEARCH
    JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
    EDUCATION
    JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
    Terms & Conditions of Use
    Privacy Policy
    Policies
    Jove
    Visualize
    Contact Us