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Phenobarbital protection against methyl mercury neophrotoxicity

B A Fowler, G W Lucier

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)

|May 1, 1975

Abstract:

Phenobarbital injections to rats given a low oral dose level of methl mercury for 2 or 4 wk decreased methyl mercury-induced ultrastructural alterations in kidney proximal tubule cells, increased urinaryexcretion of inorganic mercury and increased blood concentrations of methylmercury. These effects were not seen after 2 wk of treatment but were highly significant after 4 wk.

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