Serum antibody production--an invariable consequence of sensitization with dinitrochlorobenzene

Antibodies to the dinitrophenyl determinant as estimated by a modified antigen-binding procedure have been found in the sera of all guinea pigs with contact sensitivity to DNCB. The humoral as well as the dermal responses were detectable within 7 days after immunization and persisted for at least 10 wk.