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Behavioral screening of two mouse lines selected for different brain weight.

N V Markina1, R M Salimov, I I Poletaeva

  • 1Department of Biology, Lomonossov Moscow State University, Russia.

Progress in Neuro-Psychopharmacology & Biological Psychiatry
|July 11, 2001
PubMed
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Small brain (SB) mice exhibit heightened anxiety, pain sensitivity, and altered locomotion compared to large brain (LB) mice. Ethanol affects their maze exploration differently, impacting stereotypy similarly.

Area of Science:

  • Neuroscience
  • Behavioral Genetics

Background:

  • Brain-to-body weight ratio is a key factor in behavioral research.
  • Understanding genetic influences on brain size and behavior is crucial.

Purpose of the Study:

  • To compare behavioral phenotypes of mice selectively bred for large (LB) and small (SB) brain weights.
  • To investigate anxiety-like behaviors, pain sensitivity, and responses to ethanol in these distinct mouse lines.

Main Methods:

  • Utilized various behavioral tests including open field, cross-maze, slip funnel, and tail suspension tests.
  • Administered acute ethanol (3 g/kg) to assess its effects on maze exploration and stereotypy.
  • Compared behavioral responses between LB and SB mice lines.

Main Results:

Related Experiment Videos

  • SB mice displayed increased pain sensitivity and startle responses compared to LB mice.
  • Higher immobility in SB mice during inescapable tests indicated elevated fear/anxiety.
  • SB mice showed increased locomotion and stereotyped arm alternation in maze tests.
  • Ethanol increased maze exploration time in SB mice but decreased it in LB mice, while increasing stereotypy in both.

Conclusions:

  • Selective breeding for brain size influences behavioral traits related to anxiety, pain, and locomotion.
  • SB mice exhibit a distinct behavioral profile suggestive of higher anxiety and altered stress responses.
  • Ethanol's effects on behavior are differential between LB and SB mice, particularly concerning maze exploration efficacy.