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LSD and fixed-internal responding in the rat.

J L Altman, J B Appel

    Pharmacology, Biochemistry, and Behavior
    |March 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Lysergic acid diethylamide-25 (LSD) significantly altered rat behavior on a fixed-interval schedule. Low doses increased early responding, while high doses decreased overall and late responding, impacting timing behavior.

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    Area of Science:

    • Psychopharmacology
    • Behavioral Neuroscience
    • Animal Models

    Background:

    • The effects of psychoactive substances on operant behavior are crucial for understanding their neurobiological mechanisms.
    • Lysergic acid diethylamide-25 (LSD) is a potent psychedelic with complex effects on perception and cognition.
    • Fixed-interval (FI) schedules of reinforcement are used to study timing behavior and response patterns.

    Purpose of the Study:

    • To investigate the dose-dependent effects of lysergic acid diethylamide-25 (LSD) on the bar-pressing behavior of rats under a fixed-interval, 5-minute (FI 5) schedule.
    • To analyze how different doses of LSD influence overall response rates, early-interval responding, and late-interval responding.
    • To assess the impact of LSD on the temporal distribution of responses, quantified by the Index of Curvature.

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    Main Methods:

    • Six rats were trained on a fixed-interval, 5-minute (FI 5) schedule of reinforcement.
    • Rats received a series of six different doses of lysergic acid diethylamide-25 (LSD), ranging from 0.01 to 0.32 mg/kg.
    • Bar-pressing behavior, including overall rate, rate during the first and second halves of the interval, and the Index of Curvature, was recorded and analyzed.

    Main Results:

    • High doses of LSD (0.16, 0.32 mg/kg) resulted in a depression of overall bar-pressing rates.
    • Low doses of LSD (0.01-0.08 mg/kg) increased response rates during the initial period of the FI 5 interval.
    • High doses of LSD selectively decreased high response rates occurring in the latter half of the interval, and all but the lowest dose decreased the Index of Curvature.

    Conclusions:

    • Lysergic acid diethylamide-25 (LSD) exerts dose-dependent effects on timing behavior in rats under an FI 5 schedule.
    • The drug's impact on responding appears related to baseline response rates and the salience of temporal cues.
    • These findings contribute to understanding the behavioral pharmacology of LSD and its influence on temporal ஒழுங்குமுறை (regulation).