Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Somatic mutations in organisms with complex life histories.

M E Orive1

  • 1Department of Ecology and Evolutionary Biology, University of Kansas, Lawrence, KS 66045-7534, USA.

Theoretical Population Biology
|July 11, 2001
PubMed
Summary

Somatic mutations can impact allele frequencies in organisms with indeterminate growth and clonal reproduction. Within-organism selection can effectively purge somatic mutation loads, preventing them from exceeding meiotic mutation effects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Direct estimation of the mutation rate at dinucleotide microsatellite loci in Arabidopsis thaliana (Brassicaceae).

Heredity·2009
Same author

The effects of pollen and seed migration on nuclear-dicytoplasmic systems. I. Nonrandom associations and equilibrium structure with both maternal and paternal cytoplasmic inheritance.

Genetics·2000
Same author

The effects of pollen and seed migration on nuclear-dicytoplasmic systems. II. A new method for estimating plant gene flow from joint nuclear-cytoplasmic data.

Genetics·2000
Same author

Evolutionary consequences of mutation and selection within an individual.

Genetics·1995
Same author

Effective population size in organisms with complex life-histories.

Theoretical population biology·1993

Area of Science:

  • Evolutionary biology
  • Theoretical biology
  • Genetics

Background:

  • Organisms with indeterminate growth and clonal reproduction present unique challenges for understanding mutation dynamics.
  • Distinguishing the fate of somatic mutations (arising during mitotic division) versus meiotic mutations (arising during meiotic division) is crucial.

Purpose of the Study:

  • To develop a theoretical model for the fate of mutations in organisms with indeterminate growth and clonal reproduction.
  • To compare the relative strengths of somatic and meiotic mutation under varying conditions.
  • To investigate the impact of within-organism selection on somatic mutations.

Main Methods:

  • Development of a theoretical model focusing on allele frequencies at gamete production.
  • Analysis of mutation fate based on whether mutations arise during mitotic or meiotic cell division.

Related Experiment Videos

  • Incorporation of empirical mutation rates and demographic data from clonal corals.

    • Main Results:

    • Somatic mutation can alter allele frequencies rapidly, often exceeding meiotic mutation effects with few cell divisions.
    • Strong negative selection against somatic mutations within an individual can effectively counteract their impact.
    • Within-organism selection can purge significant mutation loads that would otherwise arise from somatic mutations.

    Conclusions:

    • The fate of mutations in clonal, indeterminately growing organisms is heavily influenced by the type of cell division (somatic vs. meiotic) and the presence of selection.
    • Selection acting within an organism plays a critical role in managing the load of somatic mutations.
    • Theoretical models are essential for predicting mutation dynamics in complex life-history strategies.