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A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry
Published on: June 5, 2019
Swine platelet antigens: section report
D Llanes1, C Arce, J P de la Lastra
1Unidad Mixta Marcadores Genéticos Moleculares, Departamento de Genética, Facultad de Veterinaria, Cordoba 14005, Spain.
Veterinary Immunology and Immunopathology
|July 11, 2001
Summary
Researchers identified 14 antibodies that bind to swine platelets. Six antibodies recognized known swine CD markers, while one identified a human CD47 marker, aiding platelet research.
Area of Science:
- Immunology
- Hematology
- Veterinary Science
Background:
- Platelets play crucial roles in hemostasis and immune responses.
- Characterizing platelet surface markers is essential for understanding swine hematology and immunology.
- Limited information exists on swine platelet-specific antigens.
Purpose of the Study:
- To identify and characterize novel antibodies that bind to swine platelets.
- To expand the repertoire of known swine platelet surface markers.
- To facilitate further research into swine platelet function and immunology.
Main Methods:
- Screening of 14 antibodies against resting and activated swine platelets.
- Utilizing known swine and human CD markers for antibody characterization.
- Employing flow cytometry and immunological assays.
Main Results:
- 14 antibodies demonstrated labeling of swine platelets.
- Six antibodies recognized previously characterized swine CD markers (CD29, CD41/61, CD46).
- One antibody recognized human CD47, with another potentially recognizing its swine homologue; five antibodies remained unclustered.
Conclusions:
- The study successfully identified multiple antibodies targeting swine platelets.
- This expands the available tools for swine platelet research.
- The findings contribute to a better understanding of swine platelet surface markers and their potential roles.
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