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Effects of forebrain microinjection of cholecystokinin on dopamine cell firing rate
M E Hamilton1, F K Weddige, A S Freeman
1Department of Pharmacology, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, USA.
Abstract:
In anesthetized rats, midbrain dopamine (DA) neuronal firing rate was differentially sensitive to focal brain microinjection of cholecystokinin peptides (CCK-4 and CCK-8) and N-methyl-D-aspartate (NMDA) into nucleus accumbens, amygdala and prefrontal cortex. Whereas changes in DA neuronal firing rate were frequently observed in response to intra-amygdalar microinjection of CCK peptides, NMDA was most effective in eliciting changes in DA neuronal activity following intra-accumbal microinjection. Thus, stimulation of amygdalar CCK receptors and accumbal excitatory amino acid receptors may participate in the afferent regulation of midbrain DA neuronal function.
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