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Updated: Aug 18, 2026

In Situ Monitoring of Diffusion of Guest Molecules in Porous Media Using Electron Paramagnetic Resonance Imaging
Published on: September 2, 2016
A novel application of NMR microscopy: measurement of water diffusion inside bioadhesive bonds
P Marshall1, J E Snaar, Y L Ng
1Institute of Pharmaceutical Sciences, University of Nottingham, NG7 2RD, Nottingham, UK. paul.marshall@reckittbenckiser.com
Abstract:
The self-diffusion coefficient of water (D) inside bioadhesive bonds formed by dry and prehydrated hydrophilic matrices has been spatially resolved using nuclear magnetic resonance (NMR) microscopy. One-dimensional profiles showing the variation of D inside bioadhesive bonds were calculated from nine diffusion-weighted profiles obtained immediately after bond formation and every 5 min for 30 min. The resulting data indicated that the hydration state of a hydrophilic matrix can significantly and dramatically influence the dynamics of water movement inside a bioadhesive bond.
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