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Role of Toll-like receptors in inflammatory response in macrophages
1Department of Immunology, University of Washington, Seattle 98195, USA. aderem@sytemsbiology.org
Critical Care Medicine
|July 11, 2001
Abstract:
The innate immune response is the first line of defense against infectious disease. It is vital that the host detect the pathogen and rapidly mount a defense. The Toll-like family of receptors have evolved to detect conserved patterns on pathogens. When stimulated, these receptors activate the inflammatory response.