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Published on: June 7, 2015
Postoperative radiotherapy of NSCLC--outcome after 3-D treatment planning
1Wilhelm-Conrad-Röntgen-Klinik, University of Giessen.
Aim:
To evaluate the benefit of postoperative radiotherapy depending on lymph node involvement in non-small-cell lung cancer (NSCLC).
Patients And Method:
Retrospective analysis of patients with NSCLC, who have been treated at the University of Giessen between 1986 and 1996 by surgery (n = 437) or surgery and 3-D planned postoperative radiotherapy with 50-60 Gy (n = 115). Evaluation of survival rates and risk of death depending on postoperative radiotherapy taking into account N-category, tumor stage, completeness of resection and performance status.
Results:
With individually 3-D planned postoperative radiotherapy there was a lower risk of death in all stages with lymph node metastases. The relative risks of death and the 95% CI were in pN1 0.64 (0.39-1.03), in pN2 0.31 (0.18-0.56) and in pN3 0.25 (0.10-0.64).
Conclusion:
Our results suggest that the risk of death in NSCLC with lymph node involvement can be reduced by individually 3-D planned postoperative radiotherapy.
