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The genetic factor in acute myocardial infarction with hypertension
1Third Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.
Insights
Genetic variations in angiotensin II (AngII) and bradykinin B2 (BK-B2) receptors are linked to hypertension and acute myocardial infarction (AMI). These genetic differences may represent a novel risk factor for these cardiovascular conditions.
Area of Science:
- Cardiovascular Genetics
- Molecular Cardiology
- Hypertension Research
Background:
- Essential hypertension and acute myocardial infarction (AMI) are significant global health concerns.
- The roles of the renin-angiotensin-aldosterone system and the kallikrein-kinin system in cardiovascular disease are well-established.
- Genetic predisposition is recognized as a contributing factor to hypertension and AMI.
Purpose of the Study:
- To investigate the association between polymorphisms in angiotensin II (AngII) receptors (type 1 and type 2) and bradykinin B2 (BK-B2) receptor and the risk of essential hypertension and AMI in a Japanese population.
- To identify specific genetic variations that may serve as risk factors for these cardiovascular conditions.
Main Methods:
- A case-control study involving 150 subjects with essential hypertension, 150 subjects with AMI (with or without hypertension), and 150 healthy controls.
- Genotyping of AngII type 1 receptor (1166 A/C), AngII type 2 receptor (3123 C/A), and BK-B2 receptor (-58T/C, exon 1) polymorphisms.
- Analysis of genotype and allele frequencies between study groups.
Main Results:
- Significant differences in genotype and allele frequencies were observed for the AngII type 2 receptor (3123 C/A) and BK-B2 receptor (-58T/C) between essential hypertension patients and controls.
- The C allele of the BK-B2 receptor (-58T/C) was significantly more prevalent in AMI patients with hypertension compared to those without hypertension.
- These findings suggest a genetic link between these receptor polymorphisms and the pathophysiology of hypertension and AMI.
Conclusions:
- Genetic variations in AngII and BK-B2 receptors are associated with essential hypertension and AMI in the Japanese population.
- These receptor gene polymorphisms may represent novel genetic risk factors for hypertension and acute myocardial infarction.
- Further research is warranted to elucidate the precise pathophysiological mechanisms linking these genetic variations to cardiovascular disease.
Abstract:
This study assessed the contribution of polymorphisms of angiotensin II (AngII) receptors and bradykinin B2 (BK-B2) receptor to hypertension and acute myocardial infarction (AMI) in a Japanese population: 150 subjects with essential hypertension, 150 subjects with AMI with/without hypertension, and 150 healthy, age- and sex-matched controls. Polymorphisms of the AngII type 1 receptor (1166 A/C) and type 2 receptor (3123 C/A), and the BK-B2 receptor (-58T/C, exon 1) were analyzed and significant differences of genotypes and allelic frequencies in the AngII type 2 receptor C/A and BK-B2 receptor -58T/C were found between the essential hypertension and control subjects. Further, a significantly higher incidence of the C allele of the BK-B2 receptor was seen in AMI subjects with hypertension compared with those without hypertension. Genetic variations in the AngII and BK-B2 receptors could prove to be significant pathophysiological mechanisms affecting essential hypertension and AMI, and genetic differences appear to be a new risk factor for these conditions.