The genetic factor in acute myocardial infarction with hypertension

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Published on: August 8, 2022

S Aoki1, S Mukae, S Itoh

  • 1Third Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.

Japanese Circulation Journal
|July 12, 2001
PubMed

Insights

Genetic variations in angiotensin II (AngII) and bradykinin B2 (BK-B2) receptors are linked to hypertension and acute myocardial infarction (AMI). These genetic differences may represent a novel risk factor for these cardiovascular conditions.

Area of Science:

  • Cardiovascular Genetics
  • Molecular Cardiology
  • Hypertension Research

Background:

  • Essential hypertension and acute myocardial infarction (AMI) are significant global health concerns.
  • The roles of the renin-angiotensin-aldosterone system and the kallikrein-kinin system in cardiovascular disease are well-established.
  • Genetic predisposition is recognized as a contributing factor to hypertension and AMI.

Purpose of the Study:

  • To investigate the association between polymorphisms in angiotensin II (AngII) receptors (type 1 and type 2) and bradykinin B2 (BK-B2) receptor and the risk of essential hypertension and AMI in a Japanese population.
  • To identify specific genetic variations that may serve as risk factors for these cardiovascular conditions.

Main Methods:

  • A case-control study involving 150 subjects with essential hypertension, 150 subjects with AMI (with or without hypertension), and 150 healthy controls.
  • Genotyping of AngII type 1 receptor (1166 A/C), AngII type 2 receptor (3123 C/A), and BK-B2 receptor (-58T/C, exon 1) polymorphisms.
  • Analysis of genotype and allele frequencies between study groups.

Main Results:

  • Significant differences in genotype and allele frequencies were observed for the AngII type 2 receptor (3123 C/A) and BK-B2 receptor (-58T/C) between essential hypertension patients and controls.
  • The C allele of the BK-B2 receptor (-58T/C) was significantly more prevalent in AMI patients with hypertension compared to those without hypertension.
  • These findings suggest a genetic link between these receptor polymorphisms and the pathophysiology of hypertension and AMI.

Conclusions:

  • Genetic variations in AngII and BK-B2 receptors are associated with essential hypertension and AMI in the Japanese population.
  • These receptor gene polymorphisms may represent novel genetic risk factors for hypertension and acute myocardial infarction.
  • Further research is warranted to elucidate the precise pathophysiological mechanisms linking these genetic variations to cardiovascular disease.

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