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Related Experiment Videos

Arginine-genotype interactions and immune status.

H Kwak1, R E. Austic, R R. Dietert

  • 1Department of Microbiology and Immunology, Cornell University, 14853, Ithaca, NY, USA

Nutrition Research (New York, N.Y.)
|July 12, 2001
PubMed
Summary

Dietary arginine levels significantly impact chicken immune responses. High arginine-requiring (HA) chickens benefit more from L-arginine supplementation, showing improved growth and immune function compared to low arginine-requiring (LA) strains.

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Influence of dietary arginine concentration on lymphoid organ growth in chickens.

Poultry science·1999

Area of Science:

  • Animal Nutrition
  • Immunology
  • Poultry Science

Background:

  • Arginine is a crucial amino acid for immune function.
  • Chicken strains exhibit varying arginine requirements for growth.

Purpose of the Study:

  • To investigate the effects of dietary arginine on selective immune responses in high (HA) and low (LA) arginine-requiring chicken strains.
  • To determine if arginine needs for immune function differ between these strains.

Main Methods:

  • Feeding HA and LA chickens diets with inadequate (0.53%) or surplus (1.53%) arginine for two weeks.
  • Assessing feed efficiency, body weight gain, thymus and spleen weights.
  • Measuring delayed-type hypersensitivity response and nitric oxide (NO) production from macrophages.

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Main Results:

  • L-arginine supplementation improved feed efficiency, body weight gain, and organ weights in HA chickens compared to LA chickens.
  • Arginine deficiency reduced delayed-type hypersensitivity and NO production in both strains.
  • HA chickens exhibited higher NO production than LA chickens after E. coli lipopolysaccharide activation.

Conclusions:

  • Dietary arginine concentration influences the immune status of chickens.
  • Chicken strains with different growth-related arginine requirements may also have distinct arginine needs for optimal immune function.