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Dendritic cells can initiate protective immune responses against malaria
1Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, New York 10010, USA.
Infection and Immunity
|July 12, 2001
Abstract:
An understanding of the antigen presentation mechanisms that mediate induction of protective immune responses against malaria is essential for the development of successful immunization approaches. Here we show that dendritic cells presenting Plasmodium yoelii sporozoite antigens are able to activate specific CD4(+) and CD8(+) T cells and initiate protective immune responses against malaria in mice.