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Genetics of airway hyperresponsiveness.
G T De Sanctis1, M Daheshia, A Daser
1Pulmonary and Critical Care Divisions, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
The Journal of Allergy and Clinical Immunology
|July 12, 2001
Summary
Understanding asthma genetics is crucial. This review focuses on mouse models to explore the genetic factors influencing airway hyperresponsiveness, a key asthma trait.
Area of Science:
- Pulmonary Medicine
- Genetics
- Immunology
Background:
- Asthma involves airway obstruction, inflammation, mucus, remodeling, and hyperreactivity.
- The genetic basis of asthma, particularly in animal models, remains incompletely understood.
- No single animal model fully replicates all human asthma features.
Purpose of the Study:
- To review the genetics of airway hyperresponsiveness (AHR) in asthma.
- To highlight the utility of mouse models for studying asthma's genetic components.
Main Methods:
- Focus on genetic studies of asthma phenotypes, specifically intrinsic airway hyperreactivity.
- Utilizing inbred mouse models to investigate genetic control of AHR.
Main Results:
- Inbred mice are valuable for dissecting the genetic factors contributing to AHR.
- Genetic studies have concentrated on specific asthma-related phenotypes due to model limitations.
Conclusions:
- The inbred mouse is a critical resource for unraveling the genetic architecture of airway hyperresponsiveness.
- Further genetic research in mouse models is essential for understanding asthma pathogenesis.
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