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Risk factors for late-onset infection following glaucoma filtration surgery
H D Jampel1, H A Quigley, L A Kerrigan-Baumrind
1Wilmer Eye Institute, Maumenee B-110, 600 N Wolfe St, Baltimore, MD 21287-9205, USA. hjampel@jhmi.edu
Archives of Ophthalmology (Chicago, Ill. : 1960)
|July 27, 2001
Summary
Glaucoma filtration surgery carries risks for late-onset infection. Full-thickness procedures, no concurrent cataract surgery, intraoperative mitomycin, and post-operative antibiotic use increase infection risk.
Area of Science:
- Ophthalmology
- Surgical Outcomes
- Infectious Disease
Background:
- Late-onset infections can complicate glaucoma filtration surgery.
- Identifying risk factors is crucial for preventing post-operative complications.
Purpose of the Study:
- To determine risk factors associated with late-onset infection after glaucoma filtration surgery.
Main Methods:
- A case-control study involving 131 infection cases and 500 controls.
- Infection defined as severe anterior chamber reaction >4 weeks post-surgery.
- Risk factors analyzed using logistic regression.
Main Results:
- Full-thickness procedures (RR 13.1) and surgery without cataract extraction (RR 2.25) increased risk.
- Intraoperative mitomycin (RR 2.48) and post-operative antibiotic use (RR 2.10-5.94) were significant risk factors.
Conclusions:
- Full-thickness glaucoma surgery and concurrent cataract surgery avoidance elevate late infection risk.
- Mitomycin use and prolonged antibiotic administration are linked to increased infection rates.