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Related Experiment Videos

Anorexia, sarcopenia, and aging.

J E Morley1

  • 1Geriatric Research, Education, and Clinical Center, St. Louis VAMC, and the Division of Geriatric Medicine, St. Louis University School of Medicine, St. Louis, Missouri, USA.

Nutrition (Burbank, Los Angeles County, Calif.)
|July 13, 2001
PubMed
Summary
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Physiologic anorexia of aging, or reduced food intake, is linked to stomach changes, hormones like testosterone and leptin, and cytokines. Depression is a common cause of pathologic weight loss in seniors.

Area of Science:

  • Gerontology
  • Gastroenterology
  • Endocrinology

Background:

  • Food intake naturally decreases with age, a phenomenon known as the anorexia of aging.
  • This decline is associated with physiological changes affecting the stomach and hormonal regulation.
  • Cytokines may also contribute to age-related anorexia and muscle loss (sarcopenia), increasing frailty.

Purpose of the Study:

  • To explore the physiological mechanisms underlying age-related decline in food intake.
  • To identify key factors contributing to anorexia and weight loss in older adults.
  • To highlight the role of specific hormones and cytokines in aging and frailty.

Main Methods:

  • The study reviews existing evidence on the physiological changes associated with aging and appetite.

Related Experiment Videos

  • It examines the roles of stomach function, cholecystokinin, testosterone, leptin, and cytokines.
  • It also considers the impact of psychological factors like depression.

    • Main Results:

    • Alterations in stomach compliance and cholecystokinin activity contribute to age-related anorexia.
    • Declining testosterone in males leads to increased leptin, further suppressing appetite.
    • Cytokines are implicated in anorexia and sarcopenia, accelerating frailty.

    Conclusions:

    • The anorexia of aging is multifactorial, involving gastrointestinal, hormonal, and inflammatory processes.
    • Treatable conditions, particularly depression, are significant causes of pathological weight loss in the elderly.
    • Understanding these factors is crucial for managing appetite decline and frailty in older populations.