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[Impact of menopause hormone replacement therapy on screening mammography reading]
N E Meye1, P Schaffer, G Hédelin
1Laboratoire d'Epidémiologie et de Santé Publique, Faculté de Médecine, 4, rue Kirschleger, 67091 Strasbourg Cedex.
Purpose:
To assess difficulties in reading screening mammographies related to hormone replacement therapy (HRT) in the setting of a breast cancer screening program. Disagreement between two readers is used as the assessment criterion.
Population And Methods:
The study population consisted of all women participating in the ADEMAS breast cancer screening program in Bas-Rhin (France). Agreement between the two radiologists was considered when the same global conclusion (call-back or not of the women for further examination) or the same conclusion for each of the nine possible lesions was observed.
Results:
HRT is associated with a higher risk of disagreement between the two radiologists on global conclusion and on opacities. Conversely, disagreement risk is lowered for microcalcifications (whether benign or malignant) for HRT users.
Conclusion:
HRT is associated with a higher risk of disagreement on global conclusion. This has an impact on whether the women should be called-back or not according to reading of breast cancer screening program mammographies.