Assessing the effect of intranasal steroids on growth
Summary
This summary is machine-generated.Childhood corticosteroid use can impact growth. While some inhaled and intranasal corticosteroids show short-term effects, long-term studies suggest minimal impact on growth, especially at lower doses.
Area Of Science
- Pediatrics
- Endocrinology
- Pharmacology
Background
- Corticosteroids are widely used for various pediatric conditions.
- Concerns exist regarding their potential impact on childhood growth and development.
Purpose Of The Study
- To evaluate the effects of different inhaled and intranasal corticosteroids on childhood growth.
- To compare short-term, intermediate, and long-term growth outcomes.
Main Methods
- Review of short-term, intermediate, and long-term studies on corticosteroid use in children.
- Analysis of growth data from studies using budesonide, methylprednisolone, mometasone furoate, and beclomethasone dipropionate.
Main Results
- Short-term studies showed budesonide and methylprednisolone affected lower-leg growth; terfenadine did not.
- Higher dose budesonide (400 microg) impacted short-term growth, while mometasone furoate (MF) did not.
- Intermediate studies showed beclomethasone dipropionate affected growth rate, but MF did not.
- Long-term retrospective studies found no significant growth impact from inhaled beclomethasone dipropionate or budesonide.
Conclusions
- Discrepancies between intermediate and long-term study findings require further investigation.
- Lowest effective corticosteroid doses with low systemic absorption should be used.
- 100 microg intranasal MF daily appears to have no significant growth suppression in children.
View abstract on PubMed