Related Experiment Video
Updated: Aug 11, 2026

Quantification of Orofacial Phenotypes in Xenopus
Published on: November 6, 2014
Cleft lip and palate
1Division of Plastic and Reconstructive Surgery, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Abstract:
The most common congenital deformity of the head and neck, cleft lip and palate, presents the surgeon with a unique esthetic and reconstructive challenge. The complexity of these deformities demands the skills of a multidisciplinary team of professionals to optimize surgical outcome. This article discusses the embryology, epidemiology, and genetics of cleft lip and palate and details the history and modern methods of their surgical correction, the proper goal of which is restoration of normal facial form and velopharyngeal function.
Related Concept Videos
Pleiotropy
Genomic Imprinting and Inheritance
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Cystic Fibrosis: Pathogenesis
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...
Tongue
Anatomical Position in the Oral Cavity
The tongue is located within the oral cavity, also known as the mouth. It is attached to the floor of the mouth by a fold of mucous membrane called the...
Cardiopulmonary Resuscitation II: ACLS Airway Management
Esophageal Achalasia

