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Updated: Oct 5, 2026

Intralymphatic Immunotherapy and Vaccination in Mice
Published on: February 2, 2014
Solvent/detergent treatment does not alter the tolerance or uptake of human normal immunoglobulin for intramuscular
G P Mould1, J A Sutton, P Matejtschuk
1Guildford Clinical Pharmacology Unit, Royal Surrey County Hospital, Guildford, Surrey, UK.
Background And Objectives:
The tolerability and pharmacokinetics of a solvent/detergent-treated intramuscular immunoglobulin were compared with those of the standard product.
Materials And Methods:
Single, 750-mg intramuscular (i.m.) injections were administered to a total of 36 healthy individuals: 23 in a double-blind trial and 13 in an open trial. Changes in specific serum hepatitis A and hepatitis B antibodies were monitored for a period of up to 3 months postinjection.
Results:
No serious adverse reactions were reported, and the bioavailability of the solvent/detergent-treated preparation was equivalent to that of the standard i.m. immunoglobulin.
Conclusion:
There is no evidence that solvent/detergent treatment alters the pharmacokinetics or tolerance of human normal immunoglobulin, but it offers additional assurance against potential virus transmission.
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