Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sphingolipid biosynthesis by L-PDMP after rat MCA occlusion.

M Kubota1, M Nakane, T Nakagomi

  • 1Department of Neurosurgery & Biochemistry, Teikyo University School of Medicine, Tokyo, Japan.

Acta Neurochirurgica. Supplement
|July 14, 2001
PubMed
Summary

L-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol) (L-PDMP) administration improved brain sphingolipid metabolism and enhanced memory and learning in rats after stroke. This suggests L-PDMP promotes neural function and cell survival.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dipole Strength Distribution of ^{8}He and Decay Characteristics.

Physical review letters·2026
Same author

Magicity versus Superfluidity around ^{28}O viewed from the Study of ^{30}F.

Physical review letters·2024
Same author

Publisher Correction: First observation of <sup>28</sup>O.

Nature·2023
Same author

First observation of <sup>28</sup>O.

Nature·2023
Same author

Observation of a correlated free four-neutron system.

Nature·2022
Same author

Extending the Southern Shore of the Island of Inversion to ^{28}F.

Physical review letters·2020

Area of Science:

  • Neuroscience
  • Biochemistry
  • Pharmacology

Background:

  • Glycosphingolipid biosynthesis is crucial for neuronal function.
  • L-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol) (L-PDMP) shows neurotrophic effects in vitro.
  • Cerebral artery occlusion models ischemic stroke, impacting sphingolipid metabolism and neural function.

Purpose of the Study:

  • To investigate the effects of L-PDMP on sphingolipid metabolism and behavior in a rat stroke model.
  • To assess L-PDMP's potential to improve neural function post-ischemia.

Main Methods:

  • Rats underwent permanent occlusion of the left middle cerebral artery (MCA).
  • L-PDMP was administered intraperitoneally.
  • Sphingolipid levels in the ischemic cerebral cortex were analyzed.

Related Experiment Videos

  • Behavioral changes were assessed using the Morris water maze task.

    • Main Results:

    • L-PDMP treatment increased glucosylceramide and sphingomyelin levels in the ischemic brain region.
    • Rats treated with L-PDMP demonstrated improved memory and learning acquisition in the Morris water maze.
    • These findings indicate L-PDMP influences sphingolipid metabolism in the ischemic brain.

    Conclusions:

    • L-PDMP administration positively modulates sphingolipid metabolism in the ischemic cerebral cortex.
    • L-PDMP shows potential for promoting cell survival and enhancing neural functions following ischemic stroke.
    • Further research into L-PDMP's therapeutic applications for neurological recovery is warranted.