[Live cold-adapted reassortant influenza vaccines]

The author reviews studies of live cold-adapted reassortant influenza vaccines developed in Russia and USA. These vaccines are safe and weakly reactogenic for all age groups. The vaccines (two immunizations) are highly effective in children of preschool and school age and far less effective in adults. For elderly subjects simultaneous vaccination with live and inactivated vaccines is recommended. The probability of influenza prevention by a single injection of cold-adapted vaccines is to be further investigated. Modern data indicate that cold-adapted reassortant influenza vaccines can be used for influenza prevention only in children of preschool and school age.