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Updated: Jul 13, 2026

Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus
08:28

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[Disturbances of rhythm and atrio-ventricular conduction in digitalis overdose. Case reports]

M Janion1, D Bakowski, H Brzyźkiewicz

  • 1Wojewódzki Szpital Zespolony, Oddział Kardiologii Kielce, ul. Grunwaldzka 45.

Przeglad Lekarski
|July 14, 2001
PubMed

Insights

Digitalis overdosage can cause serious heart rhythm problems. Careful dosing and understanding drug interactions are crucial for safe digitalis use and managing toxicity.

Area of Science:

  • Cardiology
  • Clinical Pharmacology

Background:

  • Digitalis glycosides are commonly prescribed for heart conditions.
  • Overdosage can lead to significant cardiac complications.

Observation:

  • Three cases of digitalis overdosage presented with complex supraventricular dysrhythmias.
  • Atrio-ventricular conduction disturbances were a key manifestation.

Findings:

  • Factors influencing digitalis plasma concentration include pharmacokinetics, bioavailability, and drug interactions.
  • Toxic manifestations of digitalis were reviewed.

Implications:

  • Emphasizes the importance of precise digitalis dosage and monitoring.
  • Highlights the need for awareness of potential drug interactions.
  • Outlines therapeutic strategies for managing digitalis intoxication.

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