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Landau Kleffner syndrome.

S Bharani¹, C Trivedi, N Shendurnikar

¹Department of Pediatrics, Medical College, Baroda-390 001, Gujarat, India. drniranjan@icenet.net

Indian Journal of Pediatrics

|July 14, 2001

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Landau Kleffner Syndrome, a rare disorder causing speech loss and seizures, was diagnosed in an eight-year-old boy. Treatment with sodium valproate showed significant improvement in his speech, behavior, and seizure frequency.

Area of Science:

Pediatric Neurology
Clinical Neuroscience
Epileptology

Background:

Landau Kleffner Syndrome (LKS) is a rare childhood neurological disorder characterized by acquired epileptic aphasia.
It presents with seizures and progressive loss of language skills, often accompanied by electroencephalography (EEG) abnormalities.
Early diagnosis and intervention are crucial for managing LKS and mitigating its long-term effects.

Observation:

An eight-year-old male child presented with generalized convulsions, evolving into partial seizures.
The patient exhibited a gradual loss of speech and generalized EEG abnormalities.
Behavioral issues including hyperkinesis were also noted.

Findings:

The diagnosis of Landau Kleffner Syndrome was established based on clinical presentation and EEG findings.

Related Experiment Videos

Sodium valproate was initiated at a dosage of 30 mg/kg/day.

The child demonstrated marked improvement in speech, behavior, and a reduction in convulsion frequency during follow-up.

Implications:

This case highlights the potential efficacy of sodium valproate in managing Landau Kleffner Syndrome.
Early anticonvulsant therapy may help in reversing or improving speech deficits and behavioral problems associated with LKS.
Further research into optimal pharmacological strategies for LKS is warranted to improve patient outcomes.