Comparison of anorganic bovine mineral with and without synthetic peptide in a sinus elevation: a case study

A new tissue-engineered bone substitute that reportedly has the capability to enhance bone regeneration over the more classical bone substitutes, such as decalcified freeze-dried bone allograft and xenograft, was evaluated in bilateral sinus procedures. Anorganic bone mineral with and without a synthetic peptide (P-15) were grafted separately in bilateral sinuses. At the time of implant placement and at four months, trephine cores were obtained and the quality of the grafts deciphered by histomorphometry. The P-15 grafted sinus yielded 45% vital bone compared with 13% for the anorganic bovine material alone. The P-15 dramatically increased the quality and quantity of grafted bone in the sinus.