Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[RGD peptides and endothelialization of biomaterials].

Z Wu1, Y Shi, H Chen

  • 1Department of Thoracic and Cardiovascular Surgery, First Affiliated Hospital, West China University of Medical Science, Chengdu 610041.

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi = Journal of Biomedical Engineering = Shengwu Yixue Gongchengxue Zazhi
|July 14, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adrenocorticotropic hormone-secreting pheochromocytomas: the exception to the rule.

Surgery·1995
Same author

The mouse obese gene. Genomic organization, promoter activity, and activation by CCAAT/enhancer-binding protein alpha.

The Journal of biological chemistry·1995
Same author

Circadian variation in coronary tone in patients with stable angina. Protective role of the endothelium.

Circulation·1995
Same author

Purification of a heteromeric CCAAT binding protein from Neurospora crassa.

Molecular & general genetics : MGG·1995
Same author

Requirement for neuregulin receptor erbB2 in neural and cardiac development.

Nature·1995
Same author

Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins.

Proceedings of the National Academy of Sciences of the United States of America·1995

The Arg-Gly-Asp (RGD) sequence in proteins promotes endothelial cell adhesion and growth on biomaterials. This review explores RGD peptides

Area of Science:

  • Biomaterials Science
  • Cell Biology
  • Biomedical Engineering

Background:

  • Endothelialization enhances biomaterial blood compatibility, crucial for cardiovascular grafts.
  • Endothelial cell attachment and growth on artificial surfaces are key to successful endothelialization.
  • The Arg-Gly-Asp (RGD) sequence in adhesive proteins is vital for cell adhesion, migration, and growth.

Purpose of the Study:

  • To review the interaction between RGD peptides and integrins.
  • To discuss factors influencing RGD peptide bioactivity.
  • To explore RGD peptide applications in biomaterial endothelialization.

Main Methods:

  • Literature review of RGD peptide interactions with integrins.
  • Analysis of factors affecting RGD peptide bioactivity.

Related Experiment Videos

  • Synthesis of current applications of RGD peptides in biomaterial endothelialization.

    • Main Results:

    • RGD peptides bind to integrins, mediating cell adhesion.
    • RGD peptide bioactivity is influenced by factors like sequence presentation and surrounding amino acids.
    • RGD peptide incorporation into biomaterials promotes endothelialization.

    Conclusions:

    • RGD peptides are critical for enhancing endothelialization of biomaterials.
    • Understanding RGD-integrin interactions can optimize biomaterial design for cardiovascular applications.
    • RGD peptide functionalization represents a promising strategy for improving blood-contacting medical devices.