[RGD peptides and endothelialization of biomaterials]

Endothelialization can remarkably improve blood compatibility of biomaterials and promote their clinical application, especially the uses of cardiovascular grafts. The attachment and growth of endothelial cells on artificial surfaces is the critical factor affecting the process of endothelialization. Many adhesive proteins contain the Arg-Gly-Asp(RGD) sequence which plays an important role in cell adhesion, migration and growth. In this review, the interaction of RGD peptides sequence and integrins, the influential factors of RGD peptides bioactivity and its application in endothelialization of biomaterials were discussed.