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Strategies for mapping susceptibility genes in age-related maculopathy
1MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK.
Eye (London, England)
|July 14, 2001
Abstract:
The prospects for mapping genes conferring susceptibility to common disorders such as age-related maculopathy have increased as a result of advances in high-throughput genotyping using single nucleotide polymorphisms. This should not obscure the magnitude of the task of identifying what are potentially a diverse group of genetic variants with small or intermediate effects on disease susceptibility. Strategies for increasing the odds of success in such an endeavour are discussed.