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A fast method to estimate kinetic constants for enzyme inhibitors
1Centre for Mathematical Biology, Mathematical Institute, Oxford UK. schnell@maths.ox.ac.uk
Acta Biotheoretica
|July 14, 2001
Abstract:
We present a method to determine the reaction type and kinetic constants for enzyme inhibitors that decreases the number of experimental assays by at least a factor of five. It is based on a new theoretical formalism in terms of concentrations that dismisses the requirement of estimating initial velocities. Expressions for the time evolution of the concentrations of all the reactants are also given.