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Related Experiment Videos

Signalling apoptosis: a radical approach.

R J Carmody1, T G Cotter

  • 1Department of Molecular and Cellular Engineering, Institute for Human Gene Therapy, University of Pennsylvania School of Medicine, Philadelphia 19104, USA. rcarmody@dolphin.upenn.edu

Redox Report : Communications in Free Radical Research
|July 14, 2001
PubMed
Summary
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Reactive oxygen species (ROS) are not just toxic but act as crucial signaling molecules in apoptosis. This review explores their targeted role in initiating and executing programmed cell death.

Area of Science:

  • Cell Biology
  • Biochemistry
  • Molecular Biology

Background:

  • Reactive oxygen species (ROS) are traditionally viewed as cytotoxic agents causing cellular damage.
  • Oxidative stress is often assumed to trigger apoptosis through widespread, random oxidation of cellular components.

Purpose of the Study:

  • To review the emerging evidence for ROS acting as signaling molecules in apoptosis.
  • To delineate the specific roles of ROS in the initiation and execution of programmed cell death.

Main Methods:

  • Literature review of recent discoveries on ROS involvement in apoptosis.
  • Analysis of evidence supporting ROS as targeted signaling molecules.

Main Results:

  • Accumulating evidence suggests ROS actively signal apoptosis initiation and execution.

Related Experiment Videos

  • ROS signaling is targeted, not random, affecting specific cellular components.
  • Enzymatic ROS generation may be a regulated signaling process, not just a byproduct.

    • Conclusions:

    • ROS play a crucial, targeted role in the initiation and execution of apoptosis.
    • Cellular antioxidants regulate ROS levels and modulate enzyme function.
    • The paradigm is shifting from ROS as purely toxic to essential signaling molecules in cell death pathways.