Neutrophil kinetics in corticosteroid induced neutrophilia measured by plasma lysozyme

A single dose of prednisone (2 mg/kg orally) resulted in a mean rise in neutrophil counts to 2.3 (range 1.5-3.6) and a mean decrease in plasma lysozyme to 0.73 (range 0.50-0.87) times the value before the steroid was given in 10 haematologically normal persons. There was no change in the intraneutrophilic lysozyme activity. It is concluded that the decrease in plasma lysozyme is compatible with a reduction in the egress of neutrophils to the tissues and a decrease in the neutrophil turnover rate.