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pH compartmented w/o/w multiple emulsion: a diffusion study.

G M Tedajo1, M Seiller, P Prognon

  • 1Laboratoire de Physico-Chimie, Pharmacotechnie et Biopharmacie UMR CNRS 8612, Centre d'Etudes Pharmaceutiques, 5 rue J.B Clément, 92296 Châtenay-Malabry, France.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|July 14, 2001
PubMed
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This study investigated diffusion in water-in-oil-in-water emulsions with different pH aqueous phases. Fickian diffusion was identified as the primary transport mechanism, controllable with octadecylamine.

Area of Science:

  • Physical Chemistry
  • Colloid Science
  • Pharmaceutical Formulation

Background:

  • Water-in-oil-in-water (w/o/w) emulsions with distinct pH aqueous phases are of pharmaceutical interest.
  • Understanding diffusion between these phases is crucial for controlled release applications.

Purpose of the Study:

  • To investigate diffusion processes between acidic inner and higher pH outer aqueous phases in w/o/w emulsions.
  • To identify the primary mechanism of acidic species transport across the oil phase.
  • To explore methods for controlling this diffusion.

Main Methods:

  • Formulation of a model w/o/w emulsion.
  • Monitoring pH and conductivity to assess species transport.
  • Investigating potential release mechanisms: globule breakdown, micellar transport, and Fickian diffusion.

Related Experiment Videos

Main Results:

  • Evidence of acidic species transport between the aqueous compartments was confirmed via pH and conductivity changes.
  • Fickian diffusion was identified as the dominant mechanism for acidic species passage across the oil phase.
  • Introduction of octadecylamine into the oil phase limited external phase acidification by forming ion pairs at the interface.

Conclusions:

  • Fickian diffusion governs acidic species transport in these w/o/w emulsions.
  • Octadecylamine effectively controls diffusion, mitigating external phase acidification.
  • These findings support the development of w/o/w emulsions for controlled pharmaceutical delivery.