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Generation of Genetically Modified Organotypic Skin Cultures Using Devitalized Human Dermis
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Design principles for composition and performance of cultured skin substitutes

S T Boyce1

  • 1Department of Surgery, University of Cincinnati, 3229 Burnet Street, 45229, Cincinnati, OH, USA. boycest@email.uc.edu

Burns : Journal of the International Society for Burn Injuries
|July 14, 2001
PubMed
Abstract

No abstract available in PubMed .

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...

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