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Cross-linking chitosan-Fe(III), an oral phosphate binder: studies in vitro and in vivo
C Bürger1, D Valcarenghi, S Sandri
1Núcleo de Investigações Químico-Farmacêuticas, Centro de Educação Superior em Ciências da Saúde, Universidade do Vale do Itajaí, Uruguai, 458, CP 360, 88302-202, Itajaí, SC, Brazil.
International Journal of Pharmaceutics
|July 14, 2001
Abstract:
The objective was to evaluate the in vitro and in vivo phosphate binding properties of cross-linked chitosan iron (III) (CH-Fe(III)-CL), a potential oral phosphate binder for treating hyperphosphatemia. At equilibrium, the in vitro phosphate binding of CH-Fe(III)-CL was 23.6 mg g(-1) for simulated gastrointestinal conditions. In hyperphosphatemic rats, CH-Fe(III)-CL was similar to iron sulfate in reducing serum phosphate by about 35%.