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Related Experiment Videos

Does sildenafil also improve breathing?

N B Charan1

  • 1Section of Pulmonary and Critical Care Medicine, Veterans Affairs Medical Center, Boise, ID 83702-4598, USA. Nirmal.Charan@med.va.gov

Chest
|July 14, 2001
PubMed
Summary
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Sildenafil for erectile dysfunction may improve lung function in some patients with chronic obstructive pulmonary disease (COPD). This study suggests sildenafil does not harm COPD lung function and may offer modest benefits.

Area of Science:

  • Pulmonology
  • Pharmacology

Background:

  • Erectile dysfunction (ED) and chronic obstructive pulmonary disease (COPD) are common conditions.
  • Sildenafil is a common treatment for ED.
  • The impact of sildenafil on pulmonary function in COPD patients is unknown.

Observation:

  • Two patients with severe COPD and ED reported improved dyspnea after taking oral sildenafil for ED.
  • Spirometry was performed on these patients.

Findings:

  • Sildenafil treatment resulted in a 24% and 12% improvement in forced expiratory volume in one second (FEV1) in the two patients.
  • Oral sildenafil did not negatively affect pulmonary function in these COPD patients.

Implications:

  • Sildenafil may offer a modest improvement in FEV1 for some COPD patients.

Related Experiment Videos

  • Further research is warranted to explore the effects of sildenafil on COPD patients.
  • Sildenafil appears safe for use in COPD patients with ED.