Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Retrieved human allografts : a clinicopathological study.

W F Enneking1, D A Campanacci

  • 1Department of Orthopaedics and Rehabilitation, University of Florida College of Medicine, Gainesville 32610-0246, USA.

The Journal of Bone and Joint Surgery. American Volume
|July 14, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Activity of chemotherapy in mesenchymal chondrosarcoma: a multicentre retrospective analysis within the Italian Sarcoma Group network.

ESMO open·2026
Same author

Proximal humeral endoprosthetic reconstruction for tumour defects : clinical outcomes of 165 patients from the MUTARS Orthopedic Registry Orthopedic Registry Europe (MORE).

Bone & joint open·2025
Same author

GPT-based chatbot tools are still unreliable in the management of prosthetic joint infections.

Musculoskeletal surgery·2024
Same author

Induced membrane technique using enriched bone grafts for treatment of posttraumatic segmental long bone defects.

Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology·2019
Same author

Cryotherapy efficacy and safety as local therapy in surgical treatment of musculoskeletal tumours. A retrospective case series of 143 patients.

Journal of biological regulators and homeostatic agents·2019
Same author

Intercalary reconstruction of femur after tumour resection: is a vascularized fibular autograft plus allograft a long-lasting solution?

The bone & joint journal·2018
Same journal

Intraoperative Surgical Smoke During Arthroplasty: Early Unhealthy-Level Exposure and Approach-Dependent Risk.

The Journal of bone and joint surgery. American volume·2026
Same journal

Osteochondral Autograft Transfer for Focal Osteochondral Defects of the Knee: Indications, Technique, Outcomes, and Future Directions.

The Journal of bone and joint surgery. American volume·2026
Same journal

Timing of Vascular Endothelial Growth Factor Inhibitor Reinitiation and Risk of Wound Complications in Spinal Metastasis Surgery.

The Journal of bone and joint surgery. American volume·2026
Same journal

Do Younger Patients Undergoing Transfibular Total Ankle Arthroplasty Achieve Outcomes Comparable with Those of Older Patients? Interpreting Nonsignificant Differences in Clinical Research: Commentary on an article by Kevin A. Schafer, MD, et al.: "Clinical and Radiographic Outcomes at a Mean of 7 Years Following Primary Transfibular Total Ankle Arthroplasty in Younger and Older Patients".

The Journal of bone and joint surgery. American volume·2026
Same journal

Clinical and Radiographic Outcomes at a Mean of 7 Years Following Primary Transfibular Total Ankle Arthroplasty in Younger and Older Patients.

The Journal of bone and joint surgery. American volume·2026
Same journal

Quantifying Protrusio Risk in the Metastatic Acetabulum: A Step Toward Precision: Commentary on an article by Will Jiang, BS, et al.: "Development of a Radiographic Scoring System to Estimate Acetabular Protrusion Risk in Patients with Osteolytic Periacetabular Metastases".

The Journal of bone and joint surgery. American volume·2026
See all related articles

Repair of massive human allografts is a slow process, taking years for bone healing and limited internal graft repair. Articular cartilage shows degeneration over time, influenced by joint stability.

Area of Science:

  • Orthopedic Surgery
  • Regenerative Medicine
  • Biomaterials Science

Background:

  • Massive human allografts are used in reconstructive surgery.
  • Understanding allograft repair mechanisms is crucial for improving outcomes.

Purpose of the Study:

  • To investigate the time-dependent repair mechanisms of massive human allografts.
  • To analyze bone healing, soft-tissue integration, and cartilage changes over time.

Main Methods:

  • Radiographic and histological analysis of 73 human allografts (2-156 months post-implantation).
  • Quantitative assessment of union, cortical repair, fracture healing, allograft-cement interface, and articular cartilage.

Main Results:

  • Cortical union averaged 12 months via external callus; bone in the gap showed no remodeling.

Related Experiment Videos

  • External graft repair reached 80% surface coverage by 2 years; internal repair was slow (15-20% by 5 years).
  • Articular cartilage showed no chondrocyte survival but preserved architecture for up to 5 years; degeneration linked to subchondral revascularization and joint instability.

    • Conclusions:

    • Allograft repair is a slow, predictable process over the first few years.
    • Repair is influenced by factors like fracture, autografting, and tumor recurrence.
    • Articular cartilage degeneration is a late complication, exacerbated by joint instability.