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[Insulin sensitivity and stress].

A Avignon1, L Monnier

  • 1Service des Maladies Métaboliques, Hôpital Lapeyronie, 34295 Montpellier CEDEX 5, France. a-avignon@chuonypellier.fr

Diabetes & Metabolism
|July 14, 2001
PubMed
Summary
This summary is machine-generated.

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Stress significantly alters carbohydrate metabolism, increasing glucose uptake and production while decreasing insulin sensitivity, leading to hyperglycemia. This metabolic adaptation supports healing by supplying energy to injured tissues and inflammatory cells.

Area of Science:

  • Biochemistry
  • Endocrinology
  • Physiology

Context:

  • Metabolic adaptation is a critical response to physiological stress.
  • Stress profoundly impacts carbohydrate metabolism, affecting glucose homeostasis.
  • Understanding these changes is vital for managing critically ill patients.

Purpose:

  • To review the key features of glucose homeostasis during stress.
  • To explore the mechanisms underlying stress-induced insulin resistance.
  • To highlight the role of cytokines and stress hormones in metabolic adaptation.

Summary:

  • Stress responses involve significant alterations in carbohydrate metabolism, including increased glucose uptake, utilization, and endogenous production.
  • Insulin sensitivity decreases, leading to impaired glucose tolerance and hyperglycemia, which preferentially fuels injured tissues and inflammatory cells.

Related Experiment Videos

  • Cytokines and stress hormones play a crucial role in mediating these adaptive metabolic changes.

    • Impact:

    • Provides a comprehensive overview of stress-induced metabolic changes.
    • Elucidates the complex interplay between stress, hormones, cytokines, and glucose metabolism.
    • Offers insights into the physiological basis of hyperglycemia in stressed individuals.