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Related Experiment Videos

Acid-suppressive therapy use associated with antihypertensive agents.

S L Chow1, A B Luzier, L DiTusa

  • 1School of Pharmacy, University at Buffalo, State University of New York, Buffalo, New York, USA.

Journal of Clinical Pharmacology
|July 17, 2001
PubMed
Summary

Certain blood pressure medications, including nitrates and calcium channel blockers (CCBs), are linked to increased use of acid-suppressive drugs for acid reflux. This association was observed in hypertensive patients.

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Area of Science:

  • Gastroenterology
  • Cardiology
  • Pharmacology

Background:

  • Nitrates and calcium channel blockers (CCBs) can reduce lower esophageal sphincter pressure.
  • This reduction may potentially trigger or worsen gastroesophageal reflux disease (GERD).

Purpose of the Study:

  • To investigate the association between antihypertensive medications (nitrates, CCBs, alpha-1 antagonists) and the use of acid-suppressive therapy in hypertensive patients.
  • To determine if specific classes of antihypertensives correlate with increased acid-suppressive drug utilization.

Main Methods:

  • Retrospective cohort study design.
  • Analysis of acid-suppressive drug use (histamine2 antagonists, proton pump inhibitors) in 15,662 treated hypertensive patients.
  • Assessment of odds ratios for acid-suppressive therapy associated with nitrate, CCB, and alpha-1 antagonist use.

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Main Results:

  • Twenty percent of the studied hypertensive patients used acid-suppressive therapy.
  • Increased use of acid-suppressive therapy was significantly associated with nitrate (OR=1.71), CCB (OR=1.46), and alpha-1 antagonist (OR=1.32) use.
  • The association appeared additive when patients used two or more of these agents; no significant difference was found among individual CCBs.

Conclusions:

  • Nitrates, CCBs, and alpha-1 antagonists are associated with increased acid-suppressive drug use in hypertensive patients.
  • The combined use of these antihypertensives may lead to additive effects on acid reflux medication needs.
  • Further research is warranted to understand the clinical and economic implications of these findings.